Research over Sugar Substitutes and its impact

Some new studies have suggested that two sugar substitutes can disrupt protein function, which otherwise plays a major role in liver detoxification and even with the metabolism of some drugs. These substitutes for sugar are also known as non-nutritive sweeteners, which will offer a sweet taste with few or nil calories.

With around 40% of Americans consuming such non-nutritive sweeteners on a daily basis, it is vital to understand how this product can affect your body. Most people fail to realize that such sweeteners are found in zero-sugar or light sugar versions of snack foods and yogurts and even in some non-food items like cosmetics, liquid medicines, and more.

Answers from the new research work:

In some of the current research works from reputed experts, it has been found that non-nutritive sweeteners like sucralose and acesulfame potassium are used the cell-free assays and liver cells, which results in some cellular processes studies like transport. 

  • It has been found that the non-nutritive sweeteners work on the activity of P-glycoprotein, which is also considered to be a multidrug resistance protein 1. 
  • It is a family of transporters working together to cleanse the body of drugs, toxins, and even drug metabolites. 
  • The sweeteners impacted the PGP activity in the liver cells at some concentrations, through consumption of common beverages and food, below the FDA maximum limits. So, it has been proven that non-nutritive sweeteners will impact detoxification in the liver.
  • These experiments will further show that the sweeteners will stimulate transport activity and bind to PGP and compete with and inhibit the transport of other substrates like drugs and their metabolites, xenobiotics, bile acids, and short-chain lipids.

Even though the researchers have stated that the study is at its preliminary stage and needs to be confirmed in clinical and preclinical studies, some of the findings have suggested that the non-nutritive sweeteners might be quite problematic for people who have taken medications that use PGP as primary detoxification transporter. It will include some antidepressants, blood pressure medicines, and antibiotics.

What the future holds:

Going through the diabetes blood test will help you to learn more about the current condition of your body if you are going for such non-sweeteners. You can get your tests done from Simira Healthcare Pvt Ltd and won’t feel a thing.

  • In case the future confirm that non-nutritive sweeteners impair the detoxification process of the body, it might be essential to study potential interactions and then determine safe consumption level for at-risk groups.
  • It might also be vital to add specified amounts of the non-nutritive sweeteners included on food labels so that people can actually better track their intake. 
  • Even though the USA FDA recommends that non-nutritive sweeteners should stay below the acceptable intake level daily, food manufacturers are needed to list them in the ingredient. 
  • The amount included right now is around 35 diet sofas for acesulfame potassium or the 8 diet sodas for sucralose per day.
  • The food manufacturers don’t have to indicate the amount of non-nutritive sweetener used in the product.

In case you want to get your tests done to understand where your body stands, then going for the hba1c test cost from Simira Healthcare Pvt Ltd will be a great call. The digital diagnostic centre is always there to help. Some researchers are even planning to use complex models of drug transport to determine the extent to which sucralose and acesulfame potassium interfere with detoxification and drug metabolism. They are further studying mixes of such sweeteners, which will be representative of how they are found in food items.